Global assembling of Academicians, Researchers, Scholars & Industry to disseminate and exchange information at 100+ Allied Academics Conferences

Speaker
Dr. S. Arulselvi
All India Institute of medical sciences (AIIMS), India
Biography

Arulselvi has done her degree in MBBS from Thanjavur Medical college, Tamil nadu, India and MD (Pathology) in Kasturba Medical College, Manipal, Karnataka. India. She is currently working as Professor in dept of Lab Medicine, JPNA Trauma centre of All India Institute of medical sciences (AIIMS), New Delhi, India. She joined this institute since 2005. She have 95 publications in various international and national indexed journals. She has completed and is currently holding various projects funded by ICMR, DST, DBT, DHR and AIIMS institute. She has been awarded the “Indo US academician and Best researcher award” in 2012. She has won 12 awards from various papers and posters in various conferences. She has also been a reviewer to various journals and Associate editor for Journal of Laboratory Physcicians.

Abstract

Background: Injury & hypoperfusion induced stimulation of the neurohumoral system leads to endothelial cell activation, glycocalyx degradation, upregulation of procoagulant/ profibrinolytic factors causing acute coagulopathy. TBI associated coagulopathy(TBI-AC) is linked with progression of haemorrhagic lesions, with an overall prevalence of 32.7% and correlates with high risks of mortality. Objective:We designed a prospective study to assess difference in markers of endotheliopathy [glycocalyx shedding (Syndecan-1) and endothelial disruption (Thrombomodulin)] among severe isolated TBI patients with/without early coagulopathy, and determine its effect on 48hr and 30 day mortality. Materials/methods: We screened for and recruited iSTBI patients (GCS ?8) at emergency department. Sampling was done, ?12 hrs. of injury after informed consent, prior to transfusion. Patients with H/O anticoagulants, liver disease, hypotension, extracranial injuries were excluded.TBI coagulopathy was defined based on conventional coagulation tests as INR?1.27 &/or PT ? 16.7sec &/or aPTT ? 28.8 sec. 20 healthy controls were included.Plasma levels of Syd-1 & TM were estimated by ELISA. 48hr &30day mortality were defined outcomes. Results: 120 cases met the inclusion criteria, aged 35.7±12.12 years, 96% males. TBI-AC was had an incident of 41.6%(50). TBI-AC occurred independently of age, gender, GCS. Compared to control, TBI patients had elevated glycocalyx shedding and no evidence of endothelial damage. Although thrombomodulin levels slightly declined, syndecan levels significantly elevated in coagulopathic compared to non-coagulopathic TBI patients [33.7(21.6-109.5) vs. 29.9(19.2-39.5); p0.03]. ROC curve revealed ?30.50 ng/mL as a cut-off for syndecan-1 to identify TBI-AC.TBI-AC was an independent predictor of mortality (61.1%; OR = 4.73; 95% CI 1.68 to 13.3).Glycocalyx shedding was elevated in non-survivors compared to survivors, regardless of TBI-AC [coagulopathic (79.5(30.5-160.5) vs. 22.1(19.9-66.7); p0.0007); non-coagulopathic (36.3(30.3-48.7 vs. 25.3(18.3-36.1); p0.03)], whereas endothelial damage was significantly elevated in non-survivors compared to survivors of only TBI-AC group and not in patients without TBI-AC [15.3(8.5-87.2) vs. 6.4(2.2-13.4). Patients stratified as endotheliopathy (syd?30.50) had high frequency of 48 hr [20.4% vs. 6.6%] and 30 day [44.1% vs. 16.4%] mortality compared to no endotheliopathy. Conclusion:TBI associated coagulopathy was prevalent in 41.6% (50), and was an independent predictor of mortality (OR = 4.73; 95% CI 1.68 to 13.3). Significant elevations in plasma syndecan associated with TBI-AC, whilst thrombomodulin levels did not vary significantly. “High” syndecan-1 levels (?30.50 ng/mL) were significantly associated with elevated risk of early mortality. We recommend clinically, timed interventions aimed at protecting and repairing the endothelium, to attenuate traumatic endotheliopathy and potentially improve outcomes in isolated TBI patients.

Allied Academies Global Conference Directory

Mail us at

Program Director
surgery@alliedgather.com
Sponsors/Exhibiting/Advertising
surgery@alliedforums.org
General Enquiry
surgery@alliedgather.com
More details about sponsorship:sponsors@alliedacademies.com

Terms and Conditions

Responsibility

The organizers hold no responsibilities or liabilities of the personal articles of attendees at the venue against any kind of theft, loss, damage, due to any reason whatsoever. Delegates are entirely responsible for the safety of their own belongings.

Insurance

No insurance, of any kind, is included along with the registration in any of the events of the organization.

Transportation

Please note that transportation and parking is the responsibility of the registrant, Allied Academies will not be liable for any actions howsoever related to transportation and parking.

Press/Media

Press permission must be obtained from Allied Academies Conference Organizing Committee prior to the event. The press will not quote speakers or delegates unless they have obtained their approval in writing. The Allied Academies is an objective third-party non-profit organization and this conference are not associated with any commercial meeting company.

Requesting an Invitation Letter

For security purposes, letter of invitation will be sent only to those individuals who had registered for the conference after payment of complete registration fee. Once registration is complete, please contact surgery@alliedgather.com to request for a personalized letter of invitation, if not received until one month before the scheduled date of the event. All the bank charges applicable during refund will be deducted from the account of the participant.

Cancellation Policy

All cancellations or modifications of registration must be made in writing to finance@alliedacademies.com

If due to any reason, Allied academies postpone an event on the scheduled date, the participant is eligible for a credit of 100% of the registration fee paid. This credit shall only be used for another event organized by Allied academies within a period of one year from the date of rescheduling. 

Postponement of event

If due to any reason, Allied academies postpone an event and the participant is unable or unwilling to attend the conference on rescheduled dates, he/she is eligible for a credit of 100% of the registration fee paid. This credit shall only be used for another event organized by Allied academies within a period of one year from the date of rescheduling.

Transfer of registration

All registrations, after payment of complete registration fee, are transferable to other persons from the same organization, if in case the person is unable to attend the event. Request for transfer of registration must be made by the registered person in writing to finance@alliedacademies.com. Details must include the full name of the replaced new registrant, their title, contact phone number, and email address. All other registration details will be assigned to the new person unless otherwise specified.

Registration can be transferred to one conference to another conference of Allied academies if the person is unable to attend one of the conferences.

However, Registration cannot be transferred if intimated within 20 days of the respective conference.

The transferred registrations will not be eligible for Refund.

This cancellation policy was last updated on November 10, 2019

Visa Information:

Keeping in view of increased security measures, we would like to request all the participants to apply for Visa as soon as possible.

Allied academies will not directly contact embassies and consulates on behalf of visa applicants. All delegates or invitees should apply for Business Visa only.

Important note for failed visa applications: Visa issues are not covered under the cancellation policy of Allied academies, including the inability to obtain a visa.

Refund Policy:

If the registrant is unable to attend and is not in a position to transfer his/her participation to another person or event, then the following refund policies apply:

Keeping in view of advance payments towards Venue, Printing, Shipping, Hotels and other overhead charges, following Refund Policy Orders are available:

  • Before 60 days of the conference: Eligible for Full Refund after deduction of $100 towards service Fee.
  • Within 60-30 days of Conference: Eligible for 50% of payment Refund
  • Within 30 days of Conference: Not eligible for Refund
  • E-Poster Payments will not be refunded.

Accommodation Cancellation Policy:

Accommodation Service Providers (Hotels) have their own cancellation policies which are applicable when cancellations are made less than 30 days prior to arrival. If in case the registrant wishes to cancel or amend the accommodation, he/ she is expected to inform the organizing authorities on a prior basis. Allied academies will advise the registrant to ensure complete awareness about the cancellation policy of your accommodation provider, prior to cancellation or modification of their booking.

Authorization Policy

Online Registration:

To register online https://surgery.alliedacademies.com/, please get authorization from your respective bank for Online International Transactions after that you can proceed for online transactions.

Offline Registration:

To register offline kindly mail us on surgery@alliedgather.com with your participation interest as Speaker or Delegate and accommodation required (yes/no) with total nights, we will provide you the Invoice for the wire transfer (bank to bank).

Soon after the Payment send us the bank receipt to confirm your registration offline.

On-Spot Registration:

You may register on-spot at the venue on the registration desk directly.

On-spot we won't give any kind of discounts or packages. For Letter of Invitation, you need to Register with $200 (Token amount) to confirm your participation remaining amount you have to pay on-spot.


MEDIA PARTNERS 


                                                          

                    

NOTE: KINDLY NOTE THAT PROVIDING TRAVEL ALLOWANCES TO ANY OF THE CONFERENCE ATTENDANCES IS NOT IN OUR POLICY  

Copyright © 2020-2021 Allied Academies, All Rights Reserved.